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ONCOSTATIN M
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DeCS
Descriptor
English
:
Oncostatin M
Descriptor
Spanish
:
Oncostatina M
Descriptor
Portuguese
:
Oncostatina M
Tree Number:
D12.644.276.374.562
D12.776.467.374.562
D23.529.374.562
Definition
English
:
A cytokine with both pro- and anti-inflammatory actions that depend upon the cellular microenvironment.
Oncostatin M
is a 28 kDa monomeric glycoprotein that is
similar
in structure to
LEUKEMIA INHIBITORY FACTOR
. Its name derives from the the
observation
that it inhibited the
growth
of tumor
cells
and augmented the
growth
of normal
fibroblasts.
Pharmacological Action:
Antineoplastic Agents
Growth Inhibitors
History Note
English
:
2007(1987)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
52283
Unique Identifier:
D053683
Occurrence in VHL
:
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